115 Profiling Conservation of DNA Methylation in Cattle.
نویسندگان
چکیده
منابع مشابه
Conservation and divergence in eukaryotic DNA methylation.
C ytosine methylation is a common DNA modification found in most eukaryotic organisms including plants, animals, and fungi (1, 2). The addition of a methyl group to cytosine nucleotides in DNA does not change the primary DNA sequence, but the covalent modification of DNA by methylation can impact gene expression and activity in a heritable fashion. This type of epigenetic regulation through DNA...
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Cytosine DNA methylation in vertebrates is widespread, but methylation in plants is found almost exclusively at transposable elements and repetitive DNA. Within regions of methylation, methylcytosines are typically found in CG, CNG, and asymmetric contexts. CG sites are maintained by a plant homolog of mammalian Dnmt1 acting on hemi-methylated DNA after replication. Methylation of CNG and asymm...
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Epigenetic changes play an essential role in cancer pathogenesis. It has been established by next-generation sequencing that more than 50% of the human cancers carry mutations in mechanisms involved in the organization of the chromatin and epigenetic regulations. DNA methylation is among the most common epigenetic changes in leukemia. In contrast to DNA mutations which are passively inherited f...
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The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...
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A high-resolution map of DNA methylation in Arabidopsis has recently been generated using high-throughput sequencing of bisulfite-converted DNA. This detailed profile measures the methylation state of most of the cytosines in the Arabidopsis genome, and allows us for the first time to address questions regarding the conservation of methylation across duplicated regions of the genome. To address...
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ژورنال
عنوان ژورنال: Journal of Animal Science
سال: 2018
ISSN: 0021-8812,1525-3163
DOI: 10.1093/jas/sky404.812